major tranquilizers
primary
Role: Treatment for schizophrenia, mania, manic states with psychotic symptom
Psychosis is caused by imbalance of dopaminergic and seratonergic neurotransmission
produces tranquilization in psychiatric or schizophrenic patients.
Schizophrenia: decreases delusion and halucinations
speech/ thinking disturbance
age: teenage to young adult
genetic preponderence
CLASSIFICATION:
- Phenothiazines
- Butyrophenone Derivative
- Thioxanthenes
- Dihydroindolones
- Dibenzoxazepine
- Diphenybutypiperidines
CNS effects
antiemetic effect
alter body temperature regulation (cold environment)
alteration of muscle-skeletal tone
endocrine alterations
potentiation of analgesics
ANS effects
α-adrenergic receptor blockade (orthostatic hypotension)
inhibition of biogenic amine uptake and adrenergergic potentiation
cholinergic-blocking effects (anti-muscarininc)
blockade of histamine and serotonin receptors
